Here's the crux: These gene therapies only alter somatic cells—that is, cells that make up the body. The changes only affect the treated person. Germline editing, on the other hand, opens an entirely ...

Base editing utilizes enzymes to modify single amino acids at the most foundational unit of DNA, called a base.

We focus on the mouse as a model organism or the development of new technologies and preclinical testing of gene editing therapies ... of in vivo genome editing, developed in part through ...

CRISPR gene editing is widely regarded as one of the most important leaps in biomedical and agricultural research, with ...

The mutation in the huntingtin (HTT) gene, which causes the incurable ... They found that mutated HTT undergoes a process called “somatic expansion,” by which the number of CAG repeats ...

The same is now possible in gene editing. Rather than employ separate tools for editing genes and regulating their expression, these distinct goals can now be combined into a single tool that can ...