EM, researchers elucidated the structure of key receptors integral to fast excitatory synaptic transmission in the rat cerebellum.

Drug discovery can be a long and complex process. Medicines for neurodegenerative diseases like Alzheimer's disease are among ...

Neurotrophin (NT) receptor signaling regulates neuronal survival, axonal and dendritic network maintenance, differentiation, and synaptic plasticity. Signaling is initiated by binding of NT to the ...

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings ...

GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human ...

Interleukin 7 Receptor overview. Interleukin-7 receptor (IL7R) is a protein found on the surface of cells. It is a receptor for interleukin-7 and also acts as a receptor for thymic stromal ...

TMEM87A is composed of an extracellular beta-sandwich domain atop a G-protein coupled receptor (GPCR)-like seven-transmembrane (7TM) domain . The extracellular beta-sandwich domain is formed by seven ...

Several of Lefkowitz’s postdocs joined them in forming Septerna, whose name is a portmanteau: “Sept” comes from the prefix for seven, a nod to the seven transmembrane domains of GPCRs that ...

The typical molecular structure of GPCRs comprises seven transmembrane alpha helices, and these domains split the receptor into intracellular C-terminus, extracellular N-terminus, three ...

This is composed of the receptor-binding domain (RBD), the transmembrane domain (TMD), and a cytoplasmic tail (CT). The NMR focused on the TMD, using a bicellar structure to mimic a lipid bilayer.