This is especially true in cancer diagnostics: for example, the serine protease plasminogen activator and its inhibitor PAI1 are among the most relevant diagnostic and prognostic markers for ...

Objectives: Diarrhoea-predominant irritable bowel syndrome (IBS-D) is characterised by elevated colonic lumenal serine protease activity. The aims of this study were (1) to investigate the origin of ...

although enzyme B appeared to be thermally more stable than enzyme A2 at pH 7.5. Both enzymes were strongly inhibited by PMSF and antipain, which suggests that they belong to collagenolytic serine ...

College of Biological Engineering, The Key Laboratory of Science and Technology for Aquaculture and Food Safety, Jimei University, Xiamen, China, 361021, and Faculty of Fisheries, Nagasaki University, ...

Protein degradation and peptide importation play an important role in Mycoplasma spp. nutrition, and proteases can play a role in host adaptation and pathogenicity. Here, we present a general survey ...

In addition, coagulation proteases activate cells by cleavage of PARs (protease-activated receptors), including PAR1 and PAR2. Direct oral anticoagulants have recently been developed to specifically ...

The approval of brensocatib for use in patients with bronchiectasis could offer the first treatment directly addressing the roots of the condition.

Epithin is a type II transmembrane serine protease that exists in a soluble and membrane‐bound form. Shedding is thought to be important in regulating its action, but little is known regarding the ...

Conclusion There is systemic upregulation of α-defensin and neutrophil protease expression in NA, which may represent proinflammatory effects on the bone marrow and the release of immature neutrophils ...

Serine alleviates inflammatory responses and is beneficial for gut health; however, whether it exerts any effects on ulcerative colitis or regulates intestinal microbiota remains unknown. We ...

Furthermore, we identified a parasite protease-dependent mechanism that reduces PD-L1 expression in our in vitro oBRB model potentially contributing to immune evasion and inflammation during OT.

Proteases belong to four main groups according to the characteristics of their catalytic sites: serine proteases, cysteine (thiol) proteases, aspartyl proteases and metalloproteases. In broad ...