We have previously identified at the amino-terminus of BRCA2 a transcriptional activation domain whose importance is highlighted by the presence of predisposing mutations and in-frame deletions in ...

An enzyme type noted in several cancers is the family of adenosine deaminases acting on RNA (ADARs). These enzymes convert ...

A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research ...

This region of the protein includes independent dimerization and catalytic domains and is responsible for binding ATP and directing trans-phosphorylation. Five conserved amino acid motifs define ...

How do fungi choose to reproduce? New research reveals a molecular switch: a protein called VeA. Its precise location inside ...

Here, we report that ectopic expression of either of two heterologous HJ resolvases, Escherichia coli RusA or human GEN1 1-527, enhances the in vivo removal of the MMS-induced X-structures in cells ...