2002). Mature miRNAs bind to the RNA-induced silencing complex (RISC) and interacting with Argonaute family proteins. Typically, miRNAs pair with complementary sequences in the 3′untranslated region ...

RNAi – functions specifically to silence, or deactivate, genes. Among other applications, it promises to be groundbreaking as ...

RISC architecture is gonna change everything.” Those absurdly geeky, incredibly prophetic words were spoken 30 years ago.

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

SINGAPORE – A new programme has been launched in Singapore to formally study the applications of ribonucleic acid (RNA) in vaccine development, as well as in disease therapy and prevention ...

This manuscript presents a detailed characterization of male and female wildtype and Ctrp10 knockout mice, and reveals that knockout mice develop female-specific obesity that is largely uncoupled from ...

This case illustrates a toxic effect of flecainide in widening the QRS complex and inducing repolarisation abnormalities on exercise testing in a 67 year old woman, who had presented breathless in ...

RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, United States Program in Molecular Medicine, University of Massachusetts Chan Medical ...