Rigel Pharmaceuticals enrolls first patient in Phase 1 study of fostamatinib
Rigel Pharmaceuticals (RIGL) announced the first patient has been enrolled in a Phase 1 study evaluating the safety and tolerability of ...
Frontiers14d
Nicotine’s impact on platelet function: insights into hemostasis mechanisms
While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear. Discussion: In conclusion, nicotine activates αIIbβ3 ...
Medscape19d
Pharmacodynamic Properties of Antiplatelet Agents
IPA: Inhibition of platelet aggregation; iv ... The combined use of antiplatelet drugs acting through different mechanisms is important in antithrombotic treatment of patients with cardiovascular ...
eLife22d
A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease
We further found that neurons with accumulation of phospho-tau immunostaining contained rG4s, that rG4 structure can drive tau aggregation, and that rG4 staining density depended on APOE genotype in ...
C&EN26d
From Plant to Pathway: Molecular Mechanisms of Ruscogenin in Preventing Amyloid-Beta Aggregation through Computational and Experimental Approaches
Department of Bioengineering and Biotechnology, Birla Institute of Technology Mesra, Ranchi, Jharkhand 835215, India ...
C&EN27d
Understanding the Molecular Mechanisms of Pyrene in Governing the Critical Metabolic Circuits of Alexandrium pacificum
Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China ...
Frontiers1mon
Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study
Additionally, intrahepatic platelet aggregation was detected and quantified ... tissue is an initiating factor in the early stages of fibrosis. Additionally, the mechanism of developing fibrotic ...