A coronavirus enzyme called papain-like protease, or PLpro, is one of two proteases that are required for the initial replication steps of the virus as well as silencing host immune responses ...

The SARS-CoV-2 papain-like protease (PLpro) plays an essential role in processing viral proteins needed for replication. In addition, the enzyme can cut and inactivate some human proteins ...

DOI: 10.1126/scisignal.ade1985 Dan Cao et al, The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING, Science Signaling (2023). DOI: 10.1126/scisignal ...

The papain-like protease (PL pro) is a vital enzyme for ... However, drinking green tea will not cure your corona infection! Like it will not heal your wounds or cure your cancer.

The COVID-19 pandemic sweeping through the globe has led to enormous efforts to understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the disease. One effort ...

The papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays essential roles in virus replication and immune evasion, presenting a promising drug target.

Study: Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates. Image Credit: Shutterstock AI Generator / Shutterstock.com A study recently published in ...

Agreement aims to advance discovery and development of novel papain-like protease (PLpro) inhibitors and potentially introduce a new class of oral antivirals in the fight against COVID-19 Expands ...