Although it mediates p53-driven repression through the canonical p53-p21-Rb axis, the potential for p53 to directly regulate DREAM targets independently of its transcriptional activity has not been ...

All four proteins physically interact and TEDC1 and TEDC2 can form a subcomplex in the absence of the tubulins, supporting an AlphaFold Multimer model of the tetramer. TEDC1 and TEDC2 localize to ...

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China. (Y.E.L., S.L., Litao Wang, Y.D., L. Wu, H.C., T ...

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, U.K. Centre for Respiratory Biology, Division of Medicine, University College London ...

Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China Introduction: The recombinant human p53 adenovirus (Ad-p53) offers a ...

Results: Our research showed that DHIE and breast cancer enriched core gene targets mainly act on epithelial cells in breast cancer tissues and significantly inhibit the growth of breast cancer by ...

These results support an AlphaFold Multimer model of the tetramer in which delta-tubulin and epsilon-tubulin are predicted to form a heterodimer. TEDC1 and TEDC2 localize to centrosomes and are ...

Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States Molecular and Cellular Biology Program, University of Massachusetts, Amherst, Massachusetts 01003, ...