Genes Dev 2004). Because p53 functions as a tetramer (i.e. it binds DNA as a tetramer), co-expression of Δ40p53 and WTp53 will form Δ40p53:WTp53 tetramers with mixed stoichiometry. This presents a ...

A naturally occurring p53 isoform, called Δ40p53 (or ΔNp53), causes accelerated ... WTp53 from the native TP53 locus, ensuring a 2:2 tetramer stoichiometry. This strategy, which is based off the ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...