Two such proteins, also known as transcription factors, were particularly interesting—p53 and RFX7 ... to be regulated from a single site. This structure increases the flexibility to control ...

Typically, the mutant tumour-associated p53 proteins have lost most or all of the normal p53 functions. Although mutation in TP53 is a frequent mechanism by which p53 function is lost in ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

Monoclonal antibodies, or mAbs, are important tools in medicine. These laboratory-made proteins are widely used in treatments ...

To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

A prominent research group from Ehime University and its close partner at Kiel University have published their third ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could ...