Every other year hundreds of scientists gather for the International p53 Workshop to discuss this single gene and its protein. However, the idea that p53 is a pivotal tumour suppressor and a ...

The p53 signaling pathway is a highly complex, multicomponent signaling ... by the E3 ubiquitin ligase Mdm2 and maintained at low protein levels during normal homeostasis. During times of stress ...

dissolution of the complex almost invariably activates the released proteins. But in the case of p53 and G6PD, transient interaction with p53 is sufficient to convert G6PD into an inactive form ...

"The p53 protein is necessary for tumor suppression ... ovarian cancer and other forms of breast cancer. Considering the complex role Rbm38 plays in cancer, Chen and his team wanted to understand ...

The enzyme produces a lipid “messenger” that causes mutant p53 to link up with heat shock proteins and promote ... "Our discovery of this new molecular complex points to several different ...

Shelby is an Assistant Editor for The Scientist. She earned her PhD from West Virginia University in immunology and microbiology and completed an AAAS Mass Media fellowship. View Full Profile. Learn ...

Written and edited by experts in the field, The p53 Protein: From Cell Regulation to Cancer from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made ...

Normally, the TP53 gene provides instructions for making the protein p53, which plays a critical role in repairing or, if it’s unable to be repaired, destroying damaged cellular DNA. It’s a ...

In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells ...

In this study, the research team demonstrated that mutant p53 not only loses its tumor-suppressing abilities but also gains the capacity to corrupt other anti-tumor proteins, including p63 and p73.

The p53 protein plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long dubbed the protein p53 as the “guardian of the ...