HMGA proteins exert their oncogenic activity through several mechanisms: induction of E2F1 and AP1 activity, induction of cyclin A expression, inactivation of p53-induced apoptosis, impairment of ...

The p53 protein directly regulates the expression of miR-200 and ... which is a part of the Drosha/p68 complex that is necessary for processing of miRs. Unlike the wild-type, mutant forms of p53 were ...

A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth ... Though the science is very complex, it is advancing, and small molecules known as MDMX inhibitors are now ...

The free form of HMGB1 can block P53 degradation by binding to the oncogenic factor P53, thereby reducing the production of lactate. Acetylation (AC); adenosine 5′-monophosphate-activated protein ...

Typically, the mutant tumour-associated p53 proteins have lost most or all of the normal p53 functions. Although mutation in TP53 is a frequent mechanism by which p53 function is lost in ...

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the ...

Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the ...

To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically ...

The way the body ages could be more resilient than previously thought, a new study suggests.

Scroll through TikTok or Instagram and you’ll be inundated with protein-centric recipes. Maximizing protein is a huge trend right now on social media—and not just in the usual suspects ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...