HMGA proteins exert their oncogenic activity through several mechanisms: induction of E2F1 and AP1 activity, induction of cyclin A expression, inactivation of p53-induced apoptosis, impairment of ...

The p53 protein directly regulates the expression of miR-200 and ... which is a part of the Drosha/p68 complex that is necessary for processing of miRs. Unlike the wild-type, mutant forms of p53 were ...

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the ...

Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the ...

The way the body ages could be more resilient than previously thought, a new study suggests.

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

This depends on the type of enzyme. The enzyme pepsin breaks down proteins in the acidic conditions of the stomach. Pepsin has an optimum of pH 2.5 and a working range of between pH 1-4.