The trial, opens new tab was to evaluate the safety and efficacy of the RNA-based vaccine called BNT165e for prevention of malaria caused by the P. falciparum parasite in healthy adults who have ...

falciparum malaria in healthy malaria-naive adults. The Phase I/IIa trial, evaluating the safety and efficacy of an investigational RNA-based vaccine to prevent P. falciparum malaria, has been ...

Health authorities are conducting tests in regions of DR Congo affected by a mystery disease that has killed 60 people. https://p.dw.com/p/4rC2q Plasmodium falciparum ...

Anopheles mosquitoes that fed on the mice—taking up the anti-prefoldin antibodies—lost much of their ability to host and transmit P. falciparum parasites. Disrupting Anopheles prefoldin proteins ...

In line with its mandate to provide member states with normative guidance on health policy, WHO has recommended the use of ...

The median age was 36.0 months in the subjects and 36.0 months in the controls, both groups were comparable (p > 0.05). Children between the ages of 1 to 5 years constituted 62.2% of the entire ...

The Phase I/II trial (NCT06069544) has enrolled 177 healthy volunteers into a trial to test the safety, efficacy and pharmacokinetics (PK) of its mRNA-based vaccine for P. falciparum malaria in ...

All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the ...

Get Instant Summarized Text (Gist) A new approach for antimalarial drug development involves using a 'Trojan horse' strategy with prodrugs activated by the human enzyme acylpeptide hydrolase (APEH ...

The molecular quality control system, called the prefoldin chaperonin system, in Anopheles mosquitoes could be a promising target for malaria control strategies.