The NOTCH family includes four receptors (NOTCH1-4) and interacts with ligands like Delta-like (DLL) and Jagged (JAG). NOTCH signaling can be canonical or noncanonical. Canonical signaling ...

The NOTCH family includes four receptors (NOTCH1-4) and interacts with ligands like Delta-like (DLL) and Jagged (JAG). NOTCH signaling can be canonical or noncanonical. Canonical signaling ...

The Notch family of transmembrane receptors comprises four members, with roles in the regulation of cell fate and growth. Following ligand binding, a conformational change in the receptor negative ...

Synthetic NOTCH receptors offer tighter control over CAR expression, and engineered therapeutic genes are designed to activate in response to tumor-specific signals. Researchers at the Institute ...

The researchers outfitted CD4+ T cells with synthetic Notch (synNotch) receptors—highly programmable chimeric receptors that detect target antigens and when bound, prompt the cell to release tailored ...

New conditionally replicative adenovirus vector with synNotch receptor gene for MIBC treatment March 25, 2025 The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...