Canada Gairdner Awards recognize the world’s most accomplished researchers whose work is improving our understanding of human ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Synthetic NOTCH receptors offer tighter control over CAR expression, and engineered therapeutic genes are designed to activate in response to tumor-specific signals. Researchers at the Institute ...

Figure 1: Key signaling pathways and targeted factors in dysregulated BC. This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS ...

New conditionally replicative adenovirus vector with synNotch receptor gene for MIBC treatment March 25, 2025 The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory.

Hotter temperatures may render natural insect repellents less effective against mosquitoes, according to a new study. Hotter temperatures may render natural insect repellents less effective ...

The development of ESCA is closely linked to the complex tumor microenvironment (TME), where chemokines and their receptors play pivotal roles. Chemokines are a class of small-molecule, secreted ...

The researchers outfitted CD4+ T cells with synthetic Notch (synNotch) receptors—highly programmable chimeric receptors that detect target antigens and when bound, prompt the cell to release tailored ...