In this study, we demonstrate that synaptic plasticity is underpinned by DDHD2-driven generation of myristic acid, which is subsequently converted to myristoyl Coenzyme A (CoA) as a substrate for ...

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Although great efforts have been made to address the bioavailability and tissue targeting of drugs, little is known about drug delivery to specific subcellular compartments that harbour the drug ...

Public housing drainage issues cause a stink for terminally-ill man A terminally-ill man hasn't showered for months because of a drainage issue in his public housing unit which causes the home to ...

§ Chemistry Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University, Chongqing 400716, China # Beibei Tranditional Chinese Medicie Hospital, Chongqing 400700, ...

To further evaluate direct statin-mediated cellular effects, spontaneously hypertensive rats (SHR), an animal model with profound vascular dysfunction on the basis of hypertension in the absence of ...

Control experiments assessed that reduction of the coenzyme has occurred within the crystal. The structure reveals that reduction of the cofactor upon acylation leads to an extensive motion of the ...