Repurposing existing therapies may help slow muscle weakness in patients with Duchenne muscular dystrophy, a new study ...

Background Dendritic cells (DCs) are the most potent antigen-presenting cells involved in initiating the immune response, presenting antigens to T cells and leading to T cell proliferation. In an ...

Despite ETI therapy, neutrophil and monocyte counts remained elevated compared with healthy controls. There was no obvious association between the ETI-related improvements in systemic inflammation and ...

Thus, in contrast with hIL-10, vIL-10 stimulates monocytes to cells that are more pro-inflammatory with reduced ability to phagocytose dying cells. Our data suggest that a lytic phase protein can ...

Monocytes are the third most frequent type of leukocytes in humans, linking innate and adaptive immunity and are critical drivers in many inflammatory diseases. Based on the differential expression of ...

Nerandomilast significantly slowed lung function decline in patients with IPF, with the 18 mg dose showing a 68.8 mL FVC decline reduction compared with placebo. The trial included 1177 patients ...

mediating monocyte function, showing the fundamental role of CCR2 in targeting monocytes to sites of inflammation. In a murine model of venous thrombosis, the CCR2 expression in monocytes could ...