Until recently, creating such grids which combine the advantages of microarrays and single-molecule experiments (SMEs) has been particularly challenging due to the mismatch between the size of these ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

Molecular machine learning (ML) underpins critical workflows in drug discovery, material science, and catalyst optimization ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Juan Casado Cordón, Professor of Physical Chemistry at the University of Malaga, considers graphene—an infinite layer of ...

The agreement ensures a continuous supply of high-purity acetylene, a crucial feedstock for HydroGraph’s detonation synthesis ...

In the 1770s, early notable chemists Joseph Priestley, Carl Wilhelm Scheele, and others synthesized and isolated the molecule. Early reports in the chemical literature from 1878 included such titles ...

Abstract: Efficient and accurate small molecule classification methods can significantly ... To solve this problem, we propose a binary classification model based on graph neural networks, which ...

Ascentage Pharma is discovering and developing small molecule drugs for the treatment of cancer that block or degrade protein targets implicated in cancer. It has active clinical programs targeting ...

What do Sudoku, AI, Rubik’s cubes, clocks and molecules have in common? They can all be reimagined as algebraic equations.

In a new study, researchers identified a molecule produced by a particular type of brain cell that reversed the cognitive decline seen in both healthy aging and dementia. It provides a deeper ...