The hetero-octameric complex BORC recruits the small G protein ARL8 to mediate the transport and localization of lysosomes. BORC-ARL8 is an essential regulatory factor in the fusion of lysosomes ...

In plants and fungi, lysosomes are called acidic vacuoles. Lysosomes are formed by the fusion of vesicles that have budded off from the trans-Golgi. The sorting system recognizes address sequences ...

In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...