Korean researchers develop new drug candidate 19c for liver fibrosis treatment Researchers unveil promising new agent 19c in ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

As noted above, stellate cell activation is the central ... protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix ...

Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

Fibrogenesis is a wound-healing response to continuous liver damage, characterized by the deposition of extracellular matrix (ECM) by activated hepatic stellate cells (HSCs) and myofibroblasts.

Although numerous compounds that target individual or multiple cells or pathways ... increased ECM and deposition (figure 1). Overall, results suggest ECM1 as a plausible potential antifibrotic ...

ECM hydrogels: basement membrane secreted by Engelbreth-Holm-Swarm mouse sarcoma cells (various trade names ... (by direct attachment or infection), or indirectly with the gut and liver by secreting ...

CAFs are activated fibroblasts that exhibit an altered phenotype and secrete various growth factors, cytokines, chemokines and extracellular matrix (ECM) proteins to promote cancer cell proliferation ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...