The cells in human bodies are subject to both chemical and mechanical forces. But until recently, scientists have not ...

Scientists at Massachusetts General Hospital have revealed how chronic liver injury alters hepatic stellate cells (HSCs), triggering the formation of fibrotic scarring in the liver. The researchers ...

For anyone who consumes alcohol, understanding these five serious liver conditions is crucial before the damage becomes ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells-star-shaped liver cells long known as the main perpetrators in liver fibrosis-have a commanding role in ...

Korean researchers develop new drug candidate 19c for liver fibrosis treatment Researchers unveil promising new agent 19c in ...

Cell therapy and oncology–focused Carisma Therapeutics started layoffs late last year. Now the company plans to wind down ...

Fibrosis is an affliction wherein cells produce excess fibrous tissue. Fibroblast cells do this to close wounds, but the process can cascade in unwanted places. Examples include cardiac fibrosis; ...

One emerging approach involves targeting liver sinusoidal endothelial cell (LSEC) glycolysis, which has been linked to inflammation and fibrosis. Quercetin, a naturally occurring flavonoid found ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...