Scientists at Massachusetts General Hospital have revealed how chronic liver injury alters hepatic stellate cells (HSCs), triggering the formation of fibrotic scarring in the liver. The researchers ...

Cell therapy and oncology–focused Carisma Therapeutics started layoffs late last year. Now the company plans to wind down ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

Another round of layoffs leaves a University of Pennsylvania spinout with only seven employees just a year after its staff ...

Following liver injury, hepatic stellate cells undergo "activation" which connotes ... Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.

In preliminary clinical trials to date and previous clinical trials with the oral formulation, GRI-0621 has been shown to improve fibrosis in multiple disease models and improve liver function tests ...

After a year of stripping back its head count and pipeline, Carisma Therapeutics is now cutting down to the bone and laying ...

Ammonia Build-Up Kills Liver Cells but Can Be Prevented Using Existing ... Shiitake-Derived Functional Food Shows Suppression of Liver Fibrosis Progression Dec. 19, 2024 — A research team ...

GRI Bio (GRI) reported interim safety results from its ongoing Phase 2a study evaluating GRI-0621 for the treatment of Idiopathic Pulmonary ...

A biotech company advancing next-generation precision therapeutics for fibrosis. Forth Therapeutics (Forth Tx) is a ...

BMS-986458 features three stereocenters, one of which epimerizes easily, Mortensen said. The drug candidate, which would be ...