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eLife16d
Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
This study presents the important finding that lysosomal damage triggers inflammatory signaling through ubiquitination and the TAB-TAK1 ... potentially by the accumulation of K63 ubiquitin in damaged ...
The EMBO Journal19d
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
PPA2 inhibits glycolysis-mediated CRC metastasis by facilitating the degradation of HIF-1α To investigate the impact of NEDD4 phosphorylation at T758 on its ubiquitination and protein degradation ...
World Scientific20d
Chicoric Acid Presented NLRP3-Mediated Pyroptosis through Mitochondrial Damage by PDPK1 Ubiquitination in an Acute Lung Injury Model
Department of Pharmacy, Second Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui, P. R. China Graduate School, Wannan Medical College, Wuhu 241001, Anhui, P. R. China These authors ...
Frontiers20d
TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization
Background: Th2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary. The immune cells of patients with ...
Hosted on MSN22d
Corsair K63 Wireless Lapboard - The Accessory You Need For Living Room Gaming!
Corsair K63 Wireless Lapboard - The Accessory You Need For Living Room Gaming! Check out all of our CES 2018 Coverage: <a href="https://www.thinkcomputers.org/tag/ces ...