Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Assess the endogenous ubiquitination level of nsp16 protein ... K29 only, K33 only, K48 only, K63 only). Thirty-six hours later, cells were treated with MG132 for 12 h. Cell lysates were then ...

PS1 undergoes ubiquitination by SEL-10 and tumor necrosis factor receptor-associated factor 6 (TRAF6) (De Strooper and Annaert, 2010). Furthermore, PS1 features a ubiquitin-binding CUE domain that ...

We thank Dr. Pilong Li for polySH3 5 and polyPRM 5 plasmids, Dr. Yanhui Xu for FKBP12 and mTOR genes, and Dr. Hongrui Wang for Nedd4 and Smurf1 genes. LC3B KO HeLa cell line was a kind gift from Dr.

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...

The study further examines the interplay between ubiquitination and key signaling pathways, including Notch, Wnt/β-catenin, Hedgehog, and Hippo-YAP, which regulate stem-like properties in cancer ...

Both rely on the expression of interferon-stimulated genes (ISGs) and the ubiquitination pathway mediated by TRIM25 to mount antiviral immune responses, effectively defending against viral infections.

Pathological cardiac hypertrophy is the abnormal enlargement of the heart muscle in response to chronic stressors such as hypertension, myocardial infarction, or valvular disease. This maladaptive ...