Trials evaluating the use of hypertonic saline solutions for resuscitation after traumatic injury have not shown an overall mortality benefit compared with isotonic fluid administration.

Patients should be monitored closely after surgery for the abrupt onset of hypotonic urine excretion and/or hyperosmolality. Once a diagnosis of diabetes insipidus is confirmed—using established ...

Fluid therapy is a cornerstone for the management of DKA and HHS. Aggressive repletion with isotonic saline expands the extracellular volume and stabilizes cardiovascular functions (15). This also has ...