Today, scientists are hunting down a different kind of shape-shifting entity in search of answers about the inner workings of cellular life: intrinsically disordered proteins. Unlike their well-known, ...

Intrinsically disordered proteins (IDPs) can dynamically change their conformations depending on their external environment and can, therefore, bind to different compounds. However, they are ...

However, recent research has revealed that many proteins contain intrinsically disordered regions (IDRs) that lack a fixed structure but play essential roles in various cellular processes.

Examining an intrinsically disordered protein: "Re" is the end-to-end distance or height, "Rg" is the radius of gyration or overall size. Proteins are essential for our human body functions.

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions ...

We are building a category-defining company that has the capability to unlock not only a new landscape of protein targets but also a new class of biologics that contain intrinsically disordered ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that damage brain cells. The process of proteins spontaneously clumping is called ...

However, not all proteins form orderly arrangements. About 30% are in an intrinsically disordered state, which makes it difficult to establish to what extent the chains of such proteins form ...

The team also found that this chaperone aided the synthesis of proteins filled with intrinsically disordered regions (IDRs). These indetermined structures within the proteins are also called floppy ...

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India ...

A new antibody discovery platform can delve deeper into the mechanisms underlying the processes behind Alzheimer’s and ...