This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

A joint study conducted by the Henan University of Technology (Zhengzhou, China) and the Food Laboratory of Zhongyuan (Henan Province, China) developed and evaluated what the researchers deemed a ...

This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption of its interaction with RXRg, similar to the family member ...

Materials Science Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, India ...

It is becoming increasingly evident that water plays an active role in noncovalent receptor–ligand association. In this study, hydrophobic cavity–ligand association in a model system is characterized ...