The liver is the major site of drug metabolism. Approximately 60 percent of marketed drugs are metabolized by hepatic CYP450s. Human liver microsomes (HLM) are an important in vitro experimental model ...

Members of the organic anion-transporting polypeptide (OATP; SLCO superfamily) family facilitate the uptake of several drugs into the liver and other relevant pharmacokinetic organs. Importantly ...

Scientists at Michigan Medicine have made a significant breakthrough in treating nonalcoholic fatty liver disease (NAFLD), a ...

[13] It may be that methadone metabolism may be altered in late pregnancy, possibly due to the effect of progestins on hepatic drug metabolism. The management of methadone dosing during pregnancy ...

Researchers at Tel Aviv University have achieved a breakthrough in drug delivery: they have successfully transported lipid ...

Next, Shulman and his team want to use their method to test the effects of these and other metabolism-related drugs on liver ...

Drug-induced liver injury (DILI) is common because it can be caused ... understanding of the mechanisms that contribute to DILI and how advances in reactive metabolism trapping have improved detection ...

Akero reported Monday strong results showing its drug efruxifermin reversed liver scarring in patients with cirrhosis caused ...

Drug metabolism can be studied using in vitro liver, lung, and stomach models. These robust human models perfectly mirror the complexity of the physiological milieu, representing a significant ...