Dysregulated hyperinflammatory response with emergency granulopoiesis was pathognomonic of high-risk endotype A. Pending further validation, gene-expression-based subclassification may be used to ...

The formation of myeloid cells is organized by a hierarchical order of self-renewing pluripotent stem cells and transient lineage-affiliated progenitor-cell stages. Myeloid differentiation fate is ...

Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held beliefs, we now know that resident macrophages in many organs are seeded during embryonic development and ...

The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta-analysis, we confirm 4 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neutrophils defend against respiratory ...

Objectives Our current understanding of the genetic architecture of childhood-onset SLE (cSLE) is limited by a dearth of comprehensive genomic studies in cSLE. We have quantified the number of known ...