Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic ...

Acute myeloid leukemia (AML) is a heterogeneous group ... We used oligonucleotide-based DNA microarrays to study global gene expression in ten AML+8 patients with +8 as the sole chromosomal ...

Immune cells in the bone marrow microenvironment of AML patients are key in distinguishing a response to immunotherapy.

They classified acute myeloid leukemia cells by their resemblance to gene expression of stem cells at different life stages, discovering that the normal stem cell age most reflective of leukemia ...

Mikkael A. Sekeres, MD, Sylvester Comprehensive Cancer Center, discusses the potential benefits of treosulfan, a newly ...

A research team made a pivotal discovery in the field of cancer immunotherapy. The team identified a specific population of immune cells that play a critical role in successful treatment of relapsed ...

By profiling gene expression in HSCs, we identified an RNA-binding protein called Musashi-2 that is required for normal hematopoietic stem cells and is overexpressed in patients with a worse clinical ...

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The basis of peptide vaccination is the observation that leukemia ... protein expression of PR-3. [39] Taken together, these DC vaccination studies demonstrated that DC vaccination in AML patients ...

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the ...

Dr. Radich specializes in developing methods to improve the detection and treatment of chronic and acute myeloid leukemias ... and relapse in hematological malignancies, performing gene expression and ...

Soheil Meshinchi is an expert in leukemia biology ... In considering genomic alterations in AML, they clarified the prevalence and clinical significance of mutations in the FLT3 gene and other, ...