Functional roles of GPCRs (G-protein–coupled receptors) ... Zhai P, Yamamoto M, Galeotti Jet al. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes ...

Gprotein–coupled receptors (GPCRs) 1 are modulated by a family of specific G protein–coupled receptor kinases, or GRKs. Receptor phosphorylation by GRKs is followed by binding of uncoupling proteins ...

G protein-coupled receptors (GPCRs), the largest family of membrane proteins, serve as primary targets for over 30% of FDA-approved drugs. While signaling bias among Gα subtypes is well characterized, ...

Citation: Manni S, Fregnani A, Quotti Tubi L, Spinello Z, Carraro M, Scapinello G, Visentin A, Barilà G, Pizzi M, Dei Tos AP, Vianello F, Zambello R, Gurrieri C, Semenzato G, Trentin L and Piazza F ...

Background: Infiltration of inflammatory cells into the colon plays an important role in the onset and course of inflammatory bowel disease. G-protein-coupled receptor kinase 6 (GRK6) is an ...

The role of G q/11 coupled receptors has also been corroborated in pharmacological studies, where specific V 1a (SR-49059) or V 1b (Nelivaptan) receptor antagonists completely annulled, and oxytocin ...

G-protein-coupled receptors regulate intracellular signaling by assuming two main conformational states: an active state able to bind G-protein and an inactive state. Receptor activation is ...

Real-world analysis of folate receptor alpha (FRα; FOLR1) expression in pan-tumor samples from over 6000 patients in the US. Authors : Thomas C. Krivak , Roisin Puentes , Tori Gannon , Vladislav ...