A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read. A DNA sequence is a chain of many smaller molecules called ...

Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete ...

PRISM’s genome is engineered to include a repeat sequence with a frameshift mutation. Once inside a cell, the host’s DNA replication machinery reverts the frameshift while converting the single-strand ...