Two decades ago, a link between apoptosis and cancer was recognized, following the discovery that the protein BCL-2 specifically blocked apoptotic death of B cells in follicular lymphoma.

bcl-2, CD10, cyclinD1, CD15, CD30, ALK-1, CD138 may be used in various blood cancers or hematologic malignancies. Consider follicular lymphoma (FL) in a bit more depth as an example of other ...

Follicular lymphoma (FL) is the second most common form of NHL ... inhibitor and a B-cell lymphoma 2 (BCL-2) inhibitor. This indication is approved under accelerated approval based on response rate ...

Follicular lymphoma is an indolent malignancy with a generally favorable prognosis, with survival often measured in decades.

Follicular lymphoma is a diverse disease, both biologically and clinically. Patients may present with indolent, asymptomatic disease or more aggressive, symptomatic disease with high tumor burden.

As a lymphoma survivor, I struggle with the positivity trap — sometimes, I just want my fears validated instead of being ...

Two clinical trials testing the antibody loncastuximab tesirine (Zynlonta) showed encouraging results in patients with high-risk forms of two blood cancers—follicular lymphoma and marginal zone ...

As Fedoriw and Dogan note in their 2016 review, “Follicular lymphoma is a far more heterogeneous entity than originally appreciated." 2 At a recent workshop in Istanbul, Turkey arranged by the ...

Lymphoid proliferations include benign (lymphoid hyperplasia and lymphadenitis) equivocal and malignant (lymphoma ... AtLP with follicular pattern, AtLP rich in Reed–Sternberg-like cells ...

5 “PET-CT to evaluate response to treatment in patients with follicular lymphoma has been increasingly used by clinicians in the last 2 to 3 years, and clinical trials designed since these data ...

The new use is the third for Kymriah (tisagenlecleucel) in the EU and offers patients with grade 1, 2 and 3A follicular lymphoma that has returned after two or more prior treatments a new ...