Background: Abnormal papillary muscles (PM) are often found in hypertrophic cardiomyopathy (HCM). Objective: To assess the relationship between morphological alterations of PM in patients with HCM and ...

Cell hypertrophy is the only mechanism by which podocytes can cope with increased functional demands, whereas other glomerular cells can adapt by cell proliferation. In the setting of systemically ...

Background: Resting left ventricular outflow tract obstruction (LVOTO) occurs in 25% of patients with hypertrophic cardiomyopathy (HCM) and is an important cause of symptoms and disease progression.

Aims Mavacamten, the first approved myosin inhibitor for symptomatic obstructive hypertrophic cardiomyopathy (oHCM), addresses hypercontractility and left ventricular outflow tract (LVOT) obstruction.

Four hundred participants (95 healthy, 94 hypertrophic cardiomyopathy, 95 AL, and 116 ATTR) from 56 institutions were included (269 men aged 58.5 [48.4–69.4] years). A 3-stage ML screening cascade ...

Cervical myelopathy results from compression of the spinal cord in the neck (cervical area of the spine). Symptoms of cervical myelopathy may include problems with fine motor skills, pain or stiffness ...

Ho CY, Day SM, Ashley EA, Michels M, Pereira AC, Jacoby D, Cirino AL, Fox JC, Lakdawala NK, Ware JS, et al. Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the ...

The radiological features of apophyseal joint OA include narrowing of the facet joint space, subarticular bone erosions, subchondral cysts, osteophyte formation and hypertrophy of the articular ...

Facet arthropathy is a form of low back pain caused by osteoarthritis in the facet joints (also known as zygapophyseal joints) in the spine. This condition usually affects older patients as the result ...

Introduction. Pathological cardiac hypertrophy is typically characterized by increased cardiac myocyte cell size, interstitial fibrosis, myocyte apoptosis, and contractile dysfunction (Heineke and ...

Background To assess the psychometric properties (content validity, reliability and construct validity) of generic and disease-specific health-related quality of life (HRQoL) instruments in patients ...