Edited by Wilfred van der Donk, University of Illinois at Urbana-Champaign, Urbana, IL; received November 27, 2024; accepted February 21, 2025 ...

Remember the time when the only way to alter expression of an endogenous gene in eukaryotes was to knock it out? Then came the discovery by Craig Mello and Andrew Fire in 1998 that a double ...