Sussman was less successful with ester hydrolysis, and attributes this to the poor contact attainable in the three-phase system ester–water–catalyst.

In the dipstick method, neutrophilic esterases catalyze the hydrolysis of esters to produce their respective alcohols and acids. The alcohols produced then react with a diazonium salt to produce a ...

First, monomers linked together to form esters and thioesters. These intermediates then transformed into more stable amides, resisting hydrolysis during subsequent wet phases. Some molecules ...

The team chose to focus on serine hydrolase, a much-studied enzyme that hydrolyses esters via four distinct mechanistic ... both how quickly and how efficiently each design catalysed the hydrolysis ...

They hydrolyze ANs by cleaving phosphoric acid ester groups. Depending on the subtype ... studied the key ectonucleotidase CD73 (ecto-5’-nucleotidase), which catalyzes the hydrolysis of AMP to produce ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Gerty Theresa Cori (1896-1957) was a trailblazing biochemist whose work fundamentally reformed our understanding of how cellular energy is stored and ...

Altered gut microbiome profiles correlate with anxiety and depression in humans, and work in animal models has identified ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

This short duration of action is due to the rapid enzymatic hydrolysis of succinylcholine within the organism. For prolonged muscular relaxation it has to be administered in continuous intravenous ...

Komaba Institute for Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan Department of Basic Science, Graduate School of Arts and ...