"These findings are in keeping with our 'stalled complex' hypothesis, where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid beta-protein ...

The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate into products (pink), which are released. The enzyme ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

However, the complex structure of wood has been ... and researchers did not have a suitable feed, or "substrate," for the ...

Scientists improved enzyme-based biosensors by modifying MOFs to enhance electron transfer and enzyme stability. Enzymes are ...

Each enzyme molecule has a special place called the active site where another molecule, called the substrate, fits. The substrate goes through a chemical reaction and changes into a new molecule ...

Here, the authors use full-length Mpro protein as substrate and demonstrate that L50F can promote the formation of enzyme-substrate complex and thus contribute to nirmatrelvir resistance.

This results in the particles colliding less often, which means there will be fewer successful collisions between the substrate and the enzyme’s active site. As the temperature increases ...