Previous captain Jamie George has been ruled out of Englands first Six Nations; The England squad has been hit by five injuries including Georges after the weekends club matches and new players have been called up;

England head coach Steve Borthwick has been forced to call up five players after his Six Nations squad was rocked by injury on a damaging weekend of club rugby.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,