However, cell intrinsic stresses such as endoplasmic reticulum (ER) stress, caused by the accumulation of unfolded proteins in the ER, can also activate the ISR 9. ... is essential for thermotolerance ...

Here, we report a spatially coordinated mechanism at endoplasmic reticulum–plasma membrane (ER–PM) contact sites, where Synaptotagmin 1 (SYT1) transports ... Arabidopsis AtPLC2 is a primary ...

The intestinal epithelium is susceptible to heat stress (HS), which leads to gut leakage and inflammation. However, the mechanisms underlying HS-induced intestine dysfunction have yet to be elucidated ...

Figure 1.SOCS3 regulated cardiomyocyte hypertrophy and gp130 signaling in vitro.(A) qPCR analyses of mRNA levels of eight SOCS family members, including SOCS1–7 and CIS, in hearts of Sham and ...

Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate pathogenesis of which remains elusive. It is widely accepted that endoplasmic reticulum (ER) stress and abnormal ...

This process, according to the pick's developers, takes roughly 10 minutes to return a result. In lab tests using cortisol-spiked artificial saliva, the dental pick was sensitive enough to detect ...

2.7 RNA extraction and reverse transcription qPCR (RT-qPCR) analysis. Salt stress was applied to the 10-day seedlings of QM6 and CS by the addition ... Li X, Golub N, Zhang L and Wang H (2025) Effects ...

The Trump administration has canceled $766 million awarded to drugmaker Moderna Inc. to develop a vaccine against potential pandemic influenza viruses, including the H5N1 bird flu.. The company said ...

Paraoxonase 2 is found in intracellular structures, such as the membranes of the ER or mitochondria, where it reduces superoxide formation and ER stress signaling. 115,116 Interestingly, paraoxonase 2 ...