The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...

The endoplasmic reticulum (ER) is a compartment (organelle) in eukaryotic cells that consists of membrane sacs called cisternae. Because of the bound ribosomes, the 'rough' ER is the site of ...