Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

Matrix degradation. Quantitative and qualitative changes in matrix protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular ...

Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Your liver works tirelessly as your body’s natural filtration system, processing everything you consume and protecting you from harmful substances. When it comes to alcohol, however, this ...

A research team has made further progress in the treatment of intestinal inflammation. A study shows that the semi-synthetic bile acid NorUDCA inhibits in the intestine the formation of ...

Metabolic-dysfunction-associated steatotic liver disease (MASLD) arises from excessive intrahepatic triglyceride accumulation ...

Discover preclinical studies that indicate that empagliflozin reduces liver fat, improves liver function markers, and ...

The scoring method, called the Tumor Immune Microenvironment Spatial System, or TIMES, is the first tool in the world to ...

Barclays Plc hired John Kolz from Royal Bank of Canada to co-run global equity capital markets as it looks to the business to ...