A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

A self-powered biosensor detects and destroys E. coli using enzyme-driven energy, aptamer-based recognition, and silver ion release for real-time safety.

Total revenue of $59.3 million for the fiscal year ended December 31, 2024Expect double digit growth for total revenue in 20252025 to demonstrate ...

double-stranded DNA templates for expression of gRNAs for different genome-editing applications in a cell-free one-pot reaction. Using single-molecule tracking of cohesin and CTCF during zebrafish ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

RNA oligomers were annealed in 1:1 ratio by heating to 70°C for 5 minutes and gradually cooling to room temperature to generate the double-stranded RNA oligonucleotide substrate for DHX36. For SMARCA2 ...

Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Food Science, Southwest University, Chongqing 400715, People’s Republic of China Joint International ...

Here, we leverage this integration to reveal entangled polymer dynamics at a fast time scale, which is relatively poorly understood at the single-molecule level. We used Lambda DNA as a model system ...

These lesions can result in structural damage to the DNA molecule, potentially leading to harmful mutations ... It uses the corresponding feature of the chromosomes in cells. If one of the ...

For double-stranded DNA, the effective bending deformation energy becomes non-convex for bends greater than ~ 2° per base-pair, equivalent to the curvature of a closed circular loop of ~ 160 base ...

Using single-molecule tracking in live fission yeast to investigate ... Using defined mutants in genes encoding the core Smc5/6 complex subunits, we show that the Nse3 double-stranded DNA binding ...