Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

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The second refers to diastolic blood pressure, which is the force of the blood when the heart rests between beats. Healthcare professionals measure blood pressure readings in millimeters of ...

The company shared interim results from an ongoing Phase II trial examining its recombinant antibody fusion protein.

Ziltivekimab is under clinical development by Novo Nordisk and currently in Phase III for Diastolic Heart Failure (HFpEF). According to GlobalData, Phase III drugs for Diastolic Heart Failure (HFpEF) ...

heart failure, atrial fibrillation, and adverse kidney events. In all, 21 studies were included, mostly rated at low risk of bias. TTR was defined by systolic BP (SBP) in 15 studies and by both SBP ...

Heart failure with normal systolic function has been equated to diastolic heart failure (DHF). DHF appears to be quite common in the elderly, especially in elderly women with hypertension.

Heart failure (HF) was diagnosed according to the 2022 AHA/ACC ... Patients were divided into two groups based on the evaluation of left ventricular diastolic function: the normal group (n=466, ...

Diastolic heart failure is defined clinically when signs and symptoms of heart failure are present in the presence of preserved left ventricular systolic function (ejection fraction >45%).

Heart failure with preserved ejection fraction is ... and objective evidence of left ventricular diastolic dysfunction or raised left ventricular filling pressures. In these patients, the ruling ...

Thryv Therapeutics is a biopharmaceutical company designed to develop novel therapeutics to treat QT syndrome, arrhythmias, atrial fibrillation and treatment resistant cancer diseases. The company is ...