This addition involves formation of a covalent bond called the ‘phosphodiester bond ... of DNA. Hydrogen bonds. The hydrogen bonds between the base pairs form the double helical structure of DNA.

Unlike bacterial cyclic dinucleotides, cGAMP produced by cGAS is formed by an unusual combination of one conventional 3′ to 5′ phosphodiester bond, similar to the bonds found in DNA and RNA ...

DNA is made up of adenine-thymine (AT) bonds and guanine-cytosine (GC) bonds. The frequency of each type of bond differs substantially across bacterial species. A new study uses this quirk of ...

Now, Silverman’s team has managed to produce DNA sequences that cleave amide bonds by incorporating modified nucleotides with amine, hydroxyl, or carboxyl groups (J. Am. Chem. Soc. 2016, DOI: 10 ...

RNA repair pathways rely on RNA ligases to maintain or manipulate RNA structure in ... ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to ...

In DNA, the bases are A, G, C, and T, while in RNA, uracil replaces thymine. The nucleotides are connected through phosphodiester bonds, forming a long chain. In DNA, two complementary strands of ...

It has a distinctive structure and, unlike DNA, ... The hydroxyl group at 2’ means that in the flexible regions of an RNA molecule chemicals may attack the adjacent phosphodiester bond to cleave ...