The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

DNA is a chemical polymer that is unstable in the presence of water because of its sensitivity to the addition of water across its phosphodiester bonds, which produces strand breakage 1.

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response ... seal the two ends ...