This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

New study reveals the structure of DNA helicase at the replication fork. ScienceDaily. Retrieved May 16, 2025 from www.sciencedaily.com / releases / 2017 / 01 / 170116160548.htm.

Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process Peer-Reviewed Publication. University of Illinois at Urbana-Champaign, News Bureau ...

Several cancers and genetic disorders are linked to defects in helicases that have roles in genome maintenance and stability. This Review discusses helicase-dependent DNA repair pathways and how ...

The helicase has three major components: the Mcm2-7 hexamer ring in green, which encircles the DNA strand; the Cdc45 protein in magenta; and the GINS 4-protein complex in marine blue.

Mammalian HELQ is a 3′–5′ DNA helicase with strand displacement activity. Here we show that HELQ participates in a pathway of resistance to DNA interstrand crosslinks (ICLs). Genetic ...

Role for DNA helicase . In comparing the wild-type and mutant proteins, they found the only function it was compromised for was the ability to act as a DNA helicase, unwinding DNA strands to ...

Dr. Shahid continued: "The helicase mechanism we've uncovered appears to be evolutionarily conserved from viruses to humans, providing a universal blueprint for understanding DNA replication ...

They observed that the helicase localized in foci within the nucleus, colocalizing with established markers of DNA damage (γH2AX and 53BP1). Finally, the Warren group utilized an inducible restriction ...

The helicase is already known to work for DNA sequencing, he notes, and it pulls the DNA through the pore in a controlled way. Maglia points out that the approach is limited to peptides that are 26 ...

Hepatitis C Helicase Unwinds DNA In A Spring-loaded, Three-step Process. ScienceDaily . Retrieved May 15, 2025 from www.sciencedaily.com / releases / 2007 / 07 / 070726142007.htm ...