In this report, we describe the impact of our approach of using attenuated, membrane-lytic peptides for the cytosolic targeting of bioactive proteins including saporin (ribosome-inactivating ...

Hsp104, a cytosolic chaperone and disaggregator, was necessary for the translocation of FlucSM into the matrix. Li hypothesized that Hsp104 detangles protein “hairballs” on the mitochondrial surface, ...

Therefore, cells have developed another strategy to get rid of faulty mitochondrial proteins and maintain cellular homeostasis”, says Park. “We identified the cytosolic protein Vms1 as a key component ...

In cells overexpressing the deubiquitinase, the researchers noticed an abundance of GFP, which was expressed as a cytosolic protein, floating in the cell medium. “This made me wonder how a cytosolic ...

Bottom left shows the cytosolic viscosity of untreated ALS neurons ("CTRL") and neurons treated with NMN. The intensity of the color indicates the concentration of fluorescent molecules. Credit ...

An article in Protein & Cell discusses the multifactorial ... The paper is titled "Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice." ...

This work identifies βHB as a global regulator of cytosolic protein solubility, and identifies new metabolism-related mechanistic targets for therapeutic development in aging and AD.” ...

The researchers also performed ex vivo experiments involving aged mouse brain lysates, in which they isolated cytosolic proteins to test the selective effects of βHB on misfolded proteins.

Chaperones directly bind to the misfolded protein to counteract aggregation. The eukaryotic chaperone TRiC assists in correct folding of cytosolic protein substrates and prevents protein aggregation.