This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

As part of their experiments, the researchers found that boosting ATP production using NMN rescued cytosolic fluidity by breaking up and solubilizing existing protein aggregates in axons from ALS ...

we engineered bifunctional compounds that bind to proteins in separate cellular compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuclear-localized BRD4 as a ...

The Tom22 and Tom20 cytosolic domains were resolved ... One mode is that Tom20 and Tom22 may bind to presequences and guide the protein translocation independently. The other one is that the ...

Chaperones directly bind to the misfolded protein to counteract aggregation. The eukaryotic chaperone TRiC assists in correct folding of cytosolic protein substrates and prevents protein aggregation.

We previously showed that cytosolic NiV IBs, which are formed in infected cells or in cells minimally expressing the NiV nucleocapsid proteins, are associated with the microtubule-organizing center ...

The translocase of the outer membrane (TOM complex) forms the entry gate for the vast majority of precursor proteins that are produced on cytosolic ribosomes. Surveillance of the functionality of ...

Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether ...

However, the mechanisms by which these proteins relocate and whether they exert cytosolic functions remain unknown. We find that a subset of ER luminal proteins accumulates in the cytosol of ...

Beijing National Laboratory for Molecular Science, CAS Research/Education Center for Excellence in Molecule Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of ...