Department of Chemistry, National University of Singapore, Singapore 117543, Singapore Shaanxi Institute of Flexible Electronics (SIFE) & Xi’an Key Laboratory of Biomedical Materials & Engineering, ...

Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers ...

The remainder of this review is in 3 sections. In the first, we discuss recent studies on the spatial organization of the structures responsible for calcium cycling. The second addresses the general ...

After a Dalton college student was taken into custody by ICE, the Department of Homeland Security posted on X saying her and her family will return to Mexico together. DHS says... "The family will ...

9b00585. UNC7938 improvement of cytosolic penetration of arginine-rich CPPs and of D-dfTAT, LLOME leading to a punctate distribution of Chmp1, D-dfTAT binding to FBS albumin, and expression and ...

oral MGDs degrading undruggable targets in critical I&I pathways. These may include programs with the potential to improve upon the clinical profile of cell therapies, such as CAR-T, or biologics ...

The MHC-I presentation pathway is a crucial surveillance mechanism for preventing viral infections. Consequently, many viruses have evolved sophisticated strategies to inhibit the presentation of ...

Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer. MHC-I is highly polymorphic and each allotype is ...

reduced cell fitness and an increase in ISG and AP signatures as well as cell surface Major Histocompatibility Complex (MHC) class I, mediated by RNA:DNA hybrid activation of the CGAS/STING pathway.

One popular and effective approach is gene set based analysis, which investigates the joint effect of multiple functionally related genes (eg, pathways). However, a typical gene set analysis method is ...

Rep. Don Beyer, D-Va., who represents more than 72,000 federal workers, is introducing legislation to make it easier for government employees removed under the Trump administration to rejoin ...