"Cytochrome P450 3A4 is particularly essential because it is involved in the bioinactivation of about 50% of all drugs," the journal explained, noting that these enzymes are located in epithelial ...

A previous study showed that aficamten is metabolized, in part, by the cytochrome P450 (CYP) enzyme 3A4 1. To further characterize its metabolic pathways, aficamten was evaluated with concomitant ...